CSS Focus Area


Chemical and Biological Nonproliferation and Security

Center for Strategic Security, Global Security Sciences Division
Argonne National Laboratory

Technology and Methods Development

Members of the Technology and Methods Development (TMD) team develop science- and engineering-based solutions to address critical needs in combatting chemical and biological threats. Current areas of focus include forensic analysis of biological materials and analysis of biological security threats.

Related Activities

  • Enhanced Molecular Attribution through Proteomic Signatures (EMAPS) technology developed by the TMD team provides the ability to determine forensic details of a pathogen’s origin. While the initial distinction between, for example, naturally occurring anthrax and intentionally produced anthrax can usually be achieved by traditional genomic (DNA) methods, EMAPS technology uses proteomic signatures (proteins expressed by the pathogen) to provide the forensic analyst with significantly more information about a pathogen under study. The results obtained can identify the technical expertise and laboratory resources available to the perpetrator, including the specific growth media and protocols.
  • TMD and PTA teams work closely with decision analytics scientists in Argonne’s Risk and Infrastructure Science Center (RISC) developing standardized analytical tools for assessing security risks of chemical and biological threats. This combines the PTA and TMD teams’ extensive knowledge of strategic materials, equipment, technologies, and other information of proliferation concern with decision analytics methodologies.

Biochip based on EMAPS technologyBiochip based on EMAPS technology